Wireframes are meant to help you plan the overall structure (layout of your pages)
See this article for a good overview of wireframes: https://balsamiq.com/learn/resources/articles/what-are-wireframes/
The next step after creating your wireframes is to convert the wireframes into HTML (using minimal css to create high level box containers).
After that is done, you can then proceed to add your content and CSS styling.
See this article for a good overview of the process of going from wireframes to HTML